Article
Rapid and efficient cancer cell killing mediated by high-affinity death receptor homotrimerizing TRAIL variants.
Cell death & disease - 21 Oct 2010
Reis C R, van der Sloot A M, Natoni A, Szegezdi E, Setroikromo R, Meijer M, Sjollema K, Stricher F, Cool R H, Samali A, Serrano L, Quax W J
Abstract excerpt
The tumour necrosis factor family member TNF-related apoptosis-inducing ligand (TRAIL) selectively induces apoptosis in a variety of cancer cells through the activation of death receptors 4 (DR4) and 5 (DR5) and is considered a promising anticancer therapeutic agent. As apoptosis seems to occur primarily via only one of the two death receptors in many cancer cells, the introduction of DR selectivity is thought to...
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