Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Novel transcript variants of TRAIL show different activities in activation of NF-κB and apoptosis.

Life sciences - 5 Dec 2011

Wang Pingzhang, Lu Yan, Li Changqing, Li Na, Yu Peng, Ma Dalong

Abstract excerpt

AIMS: Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) has many transcript variants, but whether they possess distinct function is not completely known. In the present study, we compared the function of these TRAIL variants. MAIN METHODS: A bioinformatics analysis was performed to examine potential TRAIL variants. For the functional study, over-expression of TRAIL isoforms was used to examine...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apoptosis
Share to Cloning, Molecular
Share to Flow Cytometry

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fluorescent Antibody Technique, Indirect

Share to NF-kappa B

Share to Reverse Transcriptase Polymerase Chain Reaction

Share to TNF-Related Apoptosis-Inducing Ligand

Share to Transcriptional Activation

Source

Identifiers

PMID: 21952139
DOI: 10.1016/j.lfs.2011.09.003

Genes

CCL20
CCL4
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Novel transcript variants of TRAIL show different activities in activation of NF-κB and apoptosis.PMID 21952139Read ↗

The TRAIL apoptotic pathway in cancer onset, progression and therapy.Semantic proximity Read ↗

Therapeutic applications of TRAIL receptor agonists in cancer and beyondSemantic proximity Read ↗

A 71-Gene Signature of TRAIL Sensitivity in Cancer CellsSemantic proximity Read ↗

Apoptosis-Inducing TNF Superfamily Ligands for Cancer TherapySemantic proximity Read ↗

TRAIL-induced cytokine production via NFKB2 pathway promotes neutrophil chemotaxis and immune suppression in triple negative breast cancersSemantic proximity Read ↗

[TNF-related apoptosis-inducing ligand signaling pathway and hematopoietic malignancies].Semantic proximity Read ↗

TRAIL as a target in anti-cancer therapy.Semantic proximity Read ↗

Kinome profiling of non-canonical TRAIL signaling reveals RIP1-Src-STAT3 dependent invasion in resistant non-small cell lung cancer cellsSemantic proximity Read ↗

2.8 A resolution crystal structure of human TRAIL, a cytokine with selective antitumor activity.Semantic proximity Read ↗

An Antagonist Decoy Receptor and a Death Domain-Containing Receptor for TRAILSemantic proximity Read ↗

DR4-selective tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) variants obtained by structure-based design.Semantic proximity Read ↗

TWEAK, a New Secreted Ligand in the Tumor Necrosis Factor Family That Weakly Induces ApoptosisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.