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Article

Molecular basis of congenital lp(a) deficiency: a frequent apo(a) 'null' mutation in caucasians.

Human molecular genetics - 1 Oct 1999

Ogorelkova M, Gruber A, Utermann G

Abstract excerpt

High plasma concentrations of lipoprotein(a) [Lp(a)], a covalent low-density lipoprotein-apolipoprotein(a) [apo(a)] complex, are associated with coronary heart disease and stroke. Heritability of Lp(a) levels is high and the major locus determining Lp(a) concentrations is the apo(a) gene. We here demonstrate that a G-->A substitution at the +1 donor splice site of the apo(a) kringle (K) IV type 8 intron occurs...

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Share to Apolipoproteins A
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Share to Carcinoma, Hepatocellular

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Kringles

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Source

Identifiers

PMID: 10484779
DOI: 10.1093/hmg/8.11.2087

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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