Article
Comprehensive analysis of genomic variation in the LPA locus and its relationship to plasma lipoprotein(a) in South Asians, Chinese, and European Caucasians.
Circulation. Cardiovascular genetics - 1 Feb 2010
Lanktree Matthew B, Anand Sonia S, Yusuf Salim, Hegele Robert A
Abstract excerpt
BACKGROUND: Functional copy number variation in the apolipoprotein(a) gene (LPA) underlies a variable number of protein kringle domains repeated in tandem in the lipoprotein(a) [Lp(a)] particle. Genomic analysis of LPA, including both single-nucleotide polymorphisms (SNPs) and kringle IV type 2 (KIV-2) copy number, has yet to be performed. METHODS AND RESULTS: First, we genotyped 49 SNPs within 100 kb of LPA in a...
Topics
- Apoprotein(a)
- Asia, Western
- Asian People
- China
- Female
- Gene Frequency
- Genetic Loci
- Genetic Variation
- Genotype
- Haplotypes
- Humans