Article
Preproendothelin-1 gene polymorphism is related to a change in vascular reactivity in the human mammary artery in vitro.
Hypertension (Dallas, Tex. : 1979) - 1 Feb 2002
Iglarz Marc, Benessiano Joëlle, Philip Ivan, Vuillaumier-Barrot Sandrine, Lasocki Sigismond, Hvass Ulrich, Durand Geneviève, Desmonts Jean-Marie, Lévy Bernard I, Henrion Daniel
Abstract excerpt
A gene polymorphism of preproendothelin-1 (a G-to-T transversion that predicts a Lys/Asn change at codon 198) associated with an increased risk of hypertension has been recently described in patients carrying the T allele. No study has yet determined the impact of this polymorphism on vascular reactivity, although a functional role for endothelin-1 in the pathophysiology of hypertension has been clarified. At...
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