Article
The deletion polymorphism of the angiotensin-converting enzyme gene is related to phenotypic differences in human arteries.
European heart journal - 1 May 1996
Buikema H, Pinto Y M, Rooks G, Grandjean J G, Schunkert H, van Gilst W H
Abstract excerpt
We hypothesized that angiotensin-converting enzyme (ACE) insertion/deletion polymorphism may be related to arterial phenotypic differences that could explain the adverse effects of deletion polymorphism. Accordingly, contractile responses to angiotensin I and II (0.1 nmol.1(-1)-1 micromol.1(-1), endothelium-dependent relaxation to methacholine (0.01-100 micromol.1(-1), and the effect of NG-monomethyl-L-arginine...
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