Article
The deletion polymorphism of the angiotensin-converting enzyme gene is related to phenotypic differences in human arteries.
European heart journal - 1 May 1996
Buikema H, Pinto Y M, Rooks G, Grandjean J G, Schunkert H, van Gilst W H
Abstract excerpt
We hypothesized that angiotensin-converting enzyme (ACE) insertion/deletion polymorphism may be related to arterial phenotypic differences that could explain the adverse effects of deletion polymorphism. Accordingly, contractile responses to angiotensin I and II (0.1 nmol.1(-1)-1 micromol.1(-1),...
Topics
- Angiotensins
- Arteries
- Endothelium, Vascular
- Female
- Gene Deletion
- Genes
- Humans
- In Vitro Techniques
- Male
- Mammary Arteries
- Methacholine Chloride
- Middle Aged
- Nitric Oxide Synthase
- Peptidyl-Dipeptidase A
- Phenotype
- Phenylephrine
- Polymorphism, Genetic
- Vasoconstriction