Article
Nucleotide sequence and biological properties of a pathogenic proviral molecular clone of neurovirulent visna virus.
Virology - 1 Mar 1993
Andrésson O S, Elser J E, Tobin G J, Greenwood J D, Gonda M A, Georgsson G, Andrésdóttir V, Benediktsdóttir E, Carlsdóttir H M, Mäntylä E O
Abstract excerpt
Intracerebral serial passage of visna virus KV1514 through three Icelandic sheep was used to select for strains with increased neurovirulence. A strain (KV1772) with increased neuropathogenicity was obtained. We isolated several proviral molecular clones from a plaque-purified biological clone of...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Cells, Cultured
- Cloning, Molecular
- DNA, Viral
- Goats
- Molecular Sequence Data
- Mutation
- Proviruses
- Sheep
- Transfection