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Article

Nucleotide sequence and biological properties of a pathogenic proviral molecular clone of neurovirulent visna virus.

Virology - 1 Mar 1993

Andrésson O S, Elser J E, Tobin G J, Greenwood J D, Gonda M A, Georgsson G, Andrésdóttir V, Benediktsdóttir E, Carlsdóttir H M, Mäntylä E O

Abstract excerpt

Intracerebral serial passage of visna virus KV1514 through three Icelandic sheep was used to select for strains with increased neurovirulence. A strain (KV1772) with increased neuropathogenicity was obtained. We isolated several proviral molecular clones from a plaque-purified biological clone of KV1772 that induced typical visna virus pathology in young sheep. One of the clones (kv72) was infectious, while...

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PMID: 8382414
DOI: 10.1006/viro.1993.1106

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