Article
Association analysis between dopamine receptor genes and bipolar affective disorder.
Psychiatry research - 30 Jun 1999
Li T, Liu X, Sham P C, Aitchison K J, Cai G, Arranz M J, Deng H, Liu J, Kirov G, Murray R M, Collier D A
Abstract excerpt
We have performed a case-control analysis of dopamine D2-like receptor (DRD2, DRD3 and DRD4) gene polymorphisms in 118 Han Chinese cases with bipolar affective disorder and 196 control subjects, and replication analysis in 157 English cases and 143 control subjects. We found association between a functional DRD2 promoter variant (P = 0.03 by allele) and the DRD2 taq1A polymorphism (P = 0.001 by allele) in Chinese...
Topics
- Adult
- Aged
- Alleles
- Asian People
- Bipolar Disorder
- Case-Control Studies
- Chi-Square Distribution
- Female
- Genetic Variation
- Genotype
- Humans
- Male
- Polymerase Chain Reaction
- Polymorphism, Genetic