Article
The interrelationship between DRIM gene expression and cytogenetic and phenotypic characteristics in human breast tumor cell lines.
BMC genomics - 22 Sept 2003
Goodison Steve, Viars Carrie, Grazzini Maren, Urquidi Virginia
Abstract excerpt
BACKGROUND: In order to facilitate the identification of genes involved in the metastatic phenotype we have previously developed a pair of cell lines from the human breast carcinoma cell line MDA-MB-435, which have diametrically opposite metastatic potential in athymic mice. Differential display analysis of this model previously identified a novel gene, DRIM (down regulated in metastasis), the decreased...
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