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Article

Patients with chronic lymphocytic leukemia with mutated VH genes presenting with Binet stage B or C form a subgroup with a poor outcome.

Haematologica - 1 Apr 2005

Tobin Gerard, Thunberg Ulf, Laurell Anna, Karlsson Karin, Aleskog Anna, Willander Kerstin, Söderberg Ola, Merup Mats, Vilpo Juhani, Hultdin Magnus, Sundström Christer, Roos Göran, Rosenquist Richard

Abstract excerpt

BACKGROUND AND OBJECTIVES: The immunoglobulin VH gene mutation status is a strong prognostic indicator in B-cell chronic lymphocytic leukemia (CLL), since unmutated VH genes are correlated with short survival. However, the traditional cut-off level dividing mutated and unmutated cases, i.e. more...

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Share to Gene Rearrangement, B-Lymphocyte, Heavy Chain

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, Immunoglobulin

Share to Immunoglobulin Variable Region

Share to Leukemia, Lymphocytic, Chronic, B-Cell

Share to Neoplasm Staging

Share to Somatic Hypermutation, Immunoglobulin

Share to Treatment Outcome

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Identifiers

PMID: 15820941

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-15820941-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Patients with chronic lymphocytic leukemia with mutated VH genes presenting with Binet stage B or C form a subgroup with a poor outcome.PMID 15820941Read ↗

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