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Article

Frequent mutations in the neurotrophic tyrosine receptor kinase gene family in large cell neuroendocrine carcinoma of the lung.

Human mutation - 1 May 2008

Marchetti Antonio, Felicioni Lara, Pelosi Giuseppe, Del Grammastro Maela, Fumagalli Caterina, Sciarrotta Mariagrazia, Malatesta Sara, Chella Antonio, Barassi Fabio, Mucilli Felice, Camplese Pierpaolo, D'Antuono Tommaso, Sacco Rocco, Buttitta Fiamma

Abstract excerpt

The neurotrophic tyrosine receptor kinase (NTRK) family is potentially implicated in tumorigenesis and progression of several neoplastic diseases, including lung cancer. We investigated a large number of pulmonary neuroendocrine tumors (PNETs) and non-small cell lung carcinomas (NSCLCs) without morphological evidence of neuroendocrine differentiation for mutations in the NTRK gene family. A total of 538 primary...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Polymorphism, Single-Stranded Conformational

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Source

Identifiers

PMID: 18293376
DOI: 10.1002/humu.20707

Genes

NTRK1
NTRK2
NTRK3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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