Article
RNA transcripts of the beta-thalassaemia allele IVS-2-654 C-->T: a small amount of normally processed beta-globin mRNA is still produced from the mutant gene.
British journal of haematology - 1 Nov 1994
Huang S Z, Zeng F Y, Ren Z R, Lu Z H, Rodgers G P, Schechter A N, Zeng Y T
Abstract excerpt
IVS-2-654 C-->T is a common Chinese beta-thalassaemia mutation. Previous studies report that this mutation resulted in the formation of an abnormally spliced mRNA and the absence of detectable normal beta-globin mRNA, hence the mutation was considered to cause beta o-thalassaemia. We recently use...
Topics
- Alleles
- Base Sequence
- Child, Preschool
- Chromatography, High Pressure Liquid
- Erythrocytes
- Gene Expression
- Globins
- Humans
- Lymphocytes
- Male
- Molecular Sequence Data
- Mutation
- RNA, Messenger
- beta-Thalassemia