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Article

TAFII mutations disrupt Dorsal activation in the Drosophila embryo.

Proceedings of the National Academy of Sciences of the United States of America - 10 Nov 1998

Zhou J, Zwicker J, Szymanski P, Levine M, Tjian R

Abstract excerpt

In this study, we present evidence that the Dorsal activator interacts with limiting amounts of the TFIID complex in the Drosophila embryo. In vitro transcription reactions and protein binding assays implicate the TAFII110 and TAFII60 subunits of the TFIID complex in contributing to Dorsal-mediated activation. Mutations in TAFII110 and TAFII60 result in altered patterns of snail and twist transcription in embryos...

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Identifiers

PMID: 9811826
DOI: 10.1073/pnas.95.23.13483
PMCID: PMC24845

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