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Article

Interaction between the (-170) CRE and the (-150) CCAAT box is necessaryfor efficient activation of the fibronectin gene promoter by cAMP and ATF-2.

FEBS letters - 3 Sept 1999

Pesce C G, Nogués G, Alonso C R, Baralle F E, Kornblihtt A R

Abstract excerpt

The fibronectin promoter contains an ATF/cyclic AMP (cAMP) response element (CRE) site two helical turns upstream of a CCAAT site with which it interacts. We investigated the effects of mutating these (-170) CRE and(-150) CCAAT elements on the promoter activity regulated by three different modulators previously known to act through CRE: ATF-2, cAMP and E1a. While the cooperation seems to play no role in E1a...

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PMID: 10471826
DOI: 10.1016/s0014-5793(99)01091-1

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