Article
Activating transcription factor 1 and CREB are important for cell survival during early mouse development.
Molecular and cellular biology - 1 Mar 2002
Bleckmann Susanne C, Blendy Julie A, Rudolph Dorothea, Monaghan A Paula, Schmid Wolfgang, Schütz Günther
Abstract excerpt
Activating transcription factor 1 (ATF1), CREB, and the cyclic AMP (cAMP) response element modulatory protein (CREM), which constitute a subfamily of the basic leucine zipper transcription factors, activate gene expression by binding as homo- or heterodimers to the cAMP response element in regulatory regions of target genes. To investigate the function of ATF1 in vivo, we inactivated the corresponding gene by...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
