Article
Paclitaxel (Taxol)-induced gene expression and cell death are both mediated by the activation of c-Jun NH2-terminal kinase (JNK/SAPK).
The Journal of biological chemistry - 23 Oct 1998
Lee L F, Li G, Templeton D J, Ting J P
Abstract excerpt
Paclitaxel (Taxol) is a novel anti-cancer drug that has shown efficacy toward several malignant tumors, particularly ovarian tumors. We reported previously that paclitaxel can induce interleukin (IL)-8 promoter activation in subgroups of ovarian cancer through the activation of both AP-1 and nucl...
Topics
- Antineoplastic Agents, Phytogenic
- Calcium-Calmodulin-Dependent Protein Kinases
- Cell Death
- DNA-Binding Proteins
- Enzyme Activation
- Female
- Gene Expression Regulation, Neoplastic
- Humans
- I-kappa B Proteins
- Interleukin-8
- JNK Mitogen-Activated Protein Kinases
- MAP Kinase Kinase Kinase 1
- Mitogen-Activated Protein Kinase 3
- Mitogen-Activated Protein Kinases