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Chromosomal instability sensitizes patient breast tumors to multipolar divisions induced by paclitaxel

8 Sept 2021

Abstract excerpt

Paclitaxel (Taxol) is a cornerstone of cancer treatment. However, its mechanism of cytotoxicity is incompletely understood and not all patients benefit from treatment. We show that patients with breast cancer did not accumulate sufficient intratumoral paclitaxel to induce mitotic arrest in tumor cells. Instead, clinically relevant concentrations induced multipolar mitotic spindle formation. However, the extent of...

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PMID: 34516829
DOI: 10.1126/scitranslmed.abd4811

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