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Article

Functions of poly(ADP-ribose) polymerase in controlling telomere length and chromosomal stability.

Nature genetics - 1 Sept 1999

d'Adda di Fagagna F, Hande M P, Tong W M, Lansdorp P M, Wang Z Q, Jackson S P

Abstract excerpt

In most eukaryotes, poly(ADP-ribose) polymerase (PARP) recognizes DNA strand interruptions generated in vivo. DNA binding by PARP triggers primarily its own modification by the sequential addition of ADP-ribose units to form polymers; this modification, in turn, causes the release of PARP from DNA ends. Studies on the effects of the disruption of the gene encoding PARP (Adprt1, formerly Adprp) in mice have...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 10471503
DOI: 10.1038/12680

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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