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Article

Normal telomere length and chromosomal end capping in poly(ADP-ribose) polymerase-deficient mice and primary cells despite increased chromosomal instability.

The Journal of cell biology - 9 Jul 2001

Samper E, Goytisolo F A, Ménissier-de Murcia J, González-Suárez E, Cigudosa J C, de Murcia G, Blasco M A

Abstract excerpt

Poly(ADP-ribose) polymerase (PARP)-1, a detector of single-strand breaks, plays a key role in the cellular response to DNA damage. PARP-1-deficient mice are hypersensitive to genotoxic agents and display genomic instability due to a DNA repair defect in the base excision repair pathway. A previous report suggested that PARP-1-deficient mice also had a severe telomeric dysfunction consisting of telomere shortening...

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Identifiers

PMID: 11448989
DOI: 10.1083/jcb.200103049
PMCID: PMC2196874

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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