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Article

Direct modification and activation of a nuclear receptor-PIP₂ complex by the inositol lipid kinase IPMK.

Science signaling - 19 Jun 2012

Blind Raymond D, Suzawa Miyuki, Ingraham Holly A

Abstract excerpt

Phosphatidylinositol 4,5-bisphosphate (PIP₂) is best known as a plasma membrane-bound regulatory lipid. Although PIP₂ and phosphoinositide-modifying enzymes coexist in the nucleus, their nuclear roles remain unclear. We showed that inositol polyphosphate multikinase (IPMK), which functions both as an inositol kinase and as a phosphoinositide 3-kinase (PI3K), interacts with the nuclear receptor steroidogenic...

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Source

Open in PubMed Open full text

Identifiers

PMID: 22715467
DOI: 10.1126/scisignal.2003111
PMCID: PMC3395721

Genes

IPMK
PTEN
PIP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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