High-resolution analysis of 9p loss in human cancer cells using single nucleotide polymorphism-based mapping arrays.

doi:10.1016/j.cancergencyto.2006.05.002

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Article

High-resolution analysis of 9p loss in human cancer cells using single nucleotide polymorphism-based mapping arrays.

Cancer genetics and cytogenetics - 1 Oct 2006

Pei Jianming, Kruger Warren D, Testa Joseph R

Abstract excerpt

Single nucleotide polymorphism (SNP) mapping arrays were used to perform DNA copy number analysis of five human cancer cell lines (four malignant mesotheliomas; one non-small cell lung carcinoma) to identify and map the end-points of deletions of 9p. All five cell lines exhibited homozygous deletions encompassing the CDKN2A (alias INK4A/ARF) and CDKN2B loci. The DNA analysis profiles demarcated precisely two...

Topics

Cell Line, Tumor
Chromosome Deletion
Chromosomes, Human, Pair 9
Humans
Multiple Myeloma
Oligonucleotide Array Sequence Analysis
Polymorphism, Single Nucleotide

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Identifiers

PMID: 16965958
DOI: 10.1016/j.cancergencyto.2006.05.002

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