Back to search

Article

NVP-BHG712 against postmenopausal osteoporosis in mice by targeting Cathepsin K

2022-11-21

Abstract excerpt

<h4>Background: </h4> and Purpose Recent evidence suggests that postmenopausal osteoporosis is associated with increased bone resorption function in osteoclasts, of which Cathepsin K is a key molecule. In this study, we aimed to screen small molecule compounds targeting Cathepsin K and evaluate whether they affect osteoclast bone resorption function. Experimental Approach We screened out the small-molecule compoun...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
e9880b98-708d-5733-adc6-a1f49075960c
DOI
10.22541/au.166902864.48107607/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
NVP-BHG712 against postmenopausal osteoporosis in mice by targeting Cathepsin KDOI 10.22541/au.166902864.48107607/v1
Alpinetin Inhibits RANKL-Induced Osteoclastogenesis and Ovariectomy-Induced Bone Loss by Modulating NFATc1 Transcription and Lysosomal FunctionSemantic proximity
Inhibition of Osteoclastogenesis and Bone Resorption in vitro and in vivo by a prenylflavonoid xanthohumol from hopsSemantic proximity
Cirsilineol inhibits RANKL-induced osteoclast activity and ovariectomy-induced bone loss via NK-κβ/ERK/p38 signaling pathwaysSemantic proximity
Small molecule inhibitors of IκB kinase signaling inhibit osteoclast formation in vitro and prevent ovariectomy‐induced bone loss in vivoSemantic proximity
Knockout and Double Knockout of Cathepsin K and Mmp9 reveals a novel function of Cathepsin K as a regulator of osteoclast gene expression and bone homeostasisSemantic proximity
Angelic Acid Prevents RANKL-Induced Osteoclastogenesis Through Pathway-Biased Inhibition of MAPK–NFATc1 SignalingSemantic proximity
Angelic Acid Prevents RANKL-Induced Osteoclastogenesis Through Pathway-Biased Inhibition of MAPK–NFATc1 SignalingSemantic proximity
Sesamolin Protects Mice From Ovariectomized Bone Loss by Inhibiting Osteoclastogenesis and RANKL-Mediated NF-κB and MAPK Signaling PathwaysSemantic proximity
IKK/NF‐κB and ROS signal axes are involved in Tenacissoside H mediated inhibitory effects on LPS‐induced inflammatory osteolysisSemantic proximity
Peiminine Suppresses RANKL-Induced Osteoclastogenesis by Inhibiting the NFATc1, ERK, and NF-κB Signaling PathwaysSemantic proximity
Fat Extract Modulates Calcium Signaling and Protects Against Hyperactive Osteoclastogenesis in Bone Remodeling with Antioxidant CapacitySemantic proximity
The Effect of Water Extract of Betaone against Osteoporosis in OVX mice by Inhibiting MAP Kinase SignalingSemantic proximity
Select a neighboring publication to make it the new centre.