Production and characterization of new monoclonal antibodies to human osteoclasts.

doi:10.1007/BF02556253

Back to search

Article

Production and characterization of new monoclonal antibodies to human osteoclasts.

Calcified tissue international - 1 Nov 1991

Nelson P N, Pringle J A, Chambers T J

Abstract excerpt

Two monoclonal antibodies raised against human osteoclastoma were found to show antiosteoclastic activity on frozen sections of tumor. Immunoreactivity was localized on the membrane surface. These antibodies exhibited no activity against tissue macrophages and human visceral tissue except kidney, where they stained tubules but not glomeruli. In addition, no activity was observed against rabbit or rat osteoclasts,...

Topics

Animals
Antibodies, Monoclonal
Bone Neoplasms
Frozen Sections
Giant Cell Tumors
Humans
Hybridomas
Immunoenzyme Techniques
Osteoclasts
Phenotype
Species Specificity
Staining and Labeling

Tumor Cells, Cultured

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 8 closest

Production and characterization of new monoclonal antibodies to human osteoclasts.PMID 1723648Read

Development and characterization of a human in vitro resorption assay: demonstration of utility using novel antiresorptive agents.Semantic proximity Read

Purification and characterization of fully functional human osteoclast precursors.Semantic proximity Read

Monoclonal antibodies that recognize antigens in human osteosarcoma cells and normal fetal osteoblasts.Semantic proximity Read

Human osteoclast culture and phenotypic characterization.Semantic proximity Read

Advances in osteoclast biology: old findings and new insights from mouse modelsSemantic proximity Read

Recent advances in osteoclast biologySemantic proximity Read

Advances in bone biology: the osteoclast.Semantic proximity Read

Activating <i>RET</i> Mutations Promotes Osteoblastic Bone Metastases in Medullary Thyroid CancerSemantic proximity Read