Article
Mutation analysis of the MEN1 tumour suppressor gene in malignant melanoma.
Melanoma research - 1 Jun 1999
Böni R, Vortmeyer A O, Huang S, Burg G, Hofbauer G, Zhuang Z
Abstract excerpt
During the initiation and progression of malignant melanoma a series of genetic events accumulate, including alterations of chromosome 11q. Recently, an important tumour suppressor gene, the multiple endocrine neoplasia type 1 (MEN1) gene, has been mapped on 11q13 and has been cloned. To assess whether the MEN1 region is involved in tumour initiation and progression, we analysed 23 primary cutaneous melanomas and...
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