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Article

Menin represses malignant phenotypes of melanoma through regulating multiple pathways.

Journal of cellular and molecular medicine - 1 Nov 2011

Gao Shu-Bin, Feng Zi-Jie, Xu Bin, Chen Yan, Zheng Hong-Hua, Yin Ping, Hua Xianxin, Jin Guang-Hui

Abstract excerpt

Substantial genetic evidence suggests that chromosome 11q is involved in regulating initiation and progression of malignant melanomas. Mutations of the MEN1 gene, located in chromosome 11q13, predispose individuals to the multiple endocrine neoplasia type 1 (MEN1) familial syndrome. MEN1 patients...

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Source

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Identifiers

PMID: 21129151
DOI: 10.1111/j.1582-4934.2010.01222.x
PMCID: PMC3822947

Genes

MEN1
PTN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21129151-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

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Menin represses malignant phenotypes of melanoma through regulating multiple pathways.PMID 21129151Read ↗

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Molecular and genetic mechanisms of tumorigenesis in multiple endocrine neoplasia type-1.Semantic proximity Read ↗

Menin in CancerSemantic proximity Read ↗

MENIN loss as a tissue-specific driver of tumorigenesis.Semantic proximity Read ↗

MEN1 Is a Melanoma Tumor Suppressor That Preserves Genomic Integrity by Stimulating Transcription of Genes That Promote Homologous Recombination-Directed DNA RepairSemantic proximity Read ↗

ERK/MAPK Signaling Drives Overexpression of the Rac-GEF, PREX1, in BRAF- and NRAS-Mutant Melanoma.Semantic proximity Read ↗

Epigenetic regulation by the menin pathwaySemantic proximity Read ↗

Targeting β-catenin signaling for therapeutic intervention in MEN1-deficient pancreatic neuroendocrine tumoursSemantic proximity Read ↗

Menin Molecular Interactions: Insights into Normal Functions and TumorigenesisSemantic proximity Read ↗

Inactivation of menin, a Smad3-interacting protein, blocks transforming growth factor type β signalingSemantic proximity Read ↗

Menin mediates epigenetic regulation via histone H3 lysine 9 methylation.Semantic proximity Read ↗

Global gene expression in neuroendocrine tumors from patients with the MEN1 syndrome.Semantic proximity Read ↗

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