Article
MEN1 gene mutations in 12 MEN1 families and their associated tumors.
European journal of endocrinology - 1 Oct 1998
Bartsch D, Kopp I, Bergenfelz A, Rieder H, Münch K, Jäger K, Deiss Y, Schudy A, Barth P, Arnold R, Rothmund M, Simon B
Abstract excerpt
Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant inherited tumor syndrome characterized by the development of multiple endocrine tumors. The gene responsible for the disease, termed MEN1 gene. has recently been isolated and germline mutations have been described in affected MEN...
Topics
- Adenoma
- Chromosomes, Human, Pair 11
- Gastrinoma
- Germ-Line Mutation
- Humans
- Insulinoma
- Loss of Heterozygosity
- Multiple Endocrine Neoplasia Type 1
- Pancreatic Neoplasms
- Parathyroid Neoplasms
- Phenotype
- Polymorphism, Single-Stranded Conformational
- Sequence Analysis, DNA
- Vipoma