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Article

Hemoglobin Calais [beta 76 (E20) Ala----Pro]: a hemoglobin variant with decreased intrinsic oxygen affinity.

Biochimica et biophysica acta - 14 Nov 1990

Wajcman H, Kister J, Marden M, Bohn B, Blouquit Y, Descamps J, Goudemand M, Poyart C, Galacteros F

Abstract excerpt

Hb Calais [beta 76 (E20) Ala----Pro] is a new human hemoglobin variant displaying a decreased oxygen affinity. The only electrophoretical difference with Hb A was a slightly more acidic isoelectric point. A 2-fold decrease in the oxygen affinity was found by equilibrium measurements performed in a suspension of intact red blood cells and in the lysate. It was confirmed by kinetic studies of the purified abnormal...

Topics

Adult
Amino Acid Sequence
Binding Sites
Female
Hemoglobins, Abnormal
Humans
Isoelectric Point
Methemoglobin
Molecular Sequence Data
Mutation
Oxygen

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Conformation

Recombination, Genetic

Source

Identifiers

PMID: 2268685
DOI: 10.1016/0925-4439(90)90013-f

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2268685-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Hemoglobin Calais [beta 76 (E20) Ala----Pro]: a hemoglobin variant with decreased intrinsic oxygen affinity.PMID 2268685Read ↗

Hb Calais [beta76(E20)Ala --> Pro]: a family study of a variant with decreased oxygen affinity.Semantic proximity Read ↗

Hemoglobin Dallas (alpha 97(G4)Asn-->Lys): functional characterization of a high oxygen affinity natural mutant.Semantic proximity Read ↗

Hb Vila Real [beta36(C2)Pro-->His]: a newly discovered high oxygen affinity variant.Semantic proximity Read ↗

Hemoglobin Jamaica plain--a sickling hemoglobin with reduced oxygen affinity.Semantic proximity Read ↗

Site-directed mutations of human hemoglobin at residue 35beta: a residue at the intersection of the alpha1beta1, alpha1beta2, and alpha1alpha2 interfaces.Semantic proximity Read ↗

A novel beta-globin variant: Hb Poços de Caldas [beta 61(E5)Lys-->Gln].Semantic proximity Read ↗

Hemoglobin Görwihl [alpha2beta(2)5(A2)Pro-->Ala], an electrophoretically silent variant with impaired glycation.Semantic proximity Read ↗

Hemoglobin Rouen (alpha-140 (HC2) Tyr-->His): alteration of the alpha-chain C-terminal region and moderate increase in oxygen affinity.Semantic proximity Read ↗

Hb Yuda or alpha 130(H13)Ala----Asp; a new alpha chain variant with low oxygen affinity.Semantic proximity Read ↗

Hb Grove City [β38(C4)Thr→Ser, ACC>AGC; HBB: c.116C>G]: a new low oxygen affinity β chain variant.Semantic proximity Read ↗

Interfacial and distal-heme pocket mutations exhibit additive effects on the structure and function of hemoglobin.Semantic proximity Read ↗

Hb Howick [beta 37(C3)Trp-->Gly]: a new high oxygen affinity variant of the alpha 1 beta 2 contact.Semantic proximity Read ↗

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