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Article

The nature of the catalytic domain of 2'-5'-oligoadenylate synthetases.

The Journal of biological chemistry - 3 Sept 1999

Sarkar S N, Ghosh A, Wang H W, Sung S S, Sen G C

Abstract excerpt

2'-5'-Oligoadenylate (2-5(A)) synthetases are a family of interferon-induced enzymes that are activated by double-stranded RNA. To understand why, unlike other DNA and RNA polymerases, they catalyze 2'-5' instead of 3'-5' phosphodiester bond formation, we used molecular modeling to compare the structure of the catalytic domain of DNA polymerase beta (pol beta) to that of a region of the P69 isozyme of 2-5(A)...

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Identifiers

PMID: 10464285
DOI: 10.1074/jbc.274.36.25535

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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