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Article

Correlation of the kinetics of finger domain mutants in RB69 DNA polymerase with its structure.

Biochemistry - 26 Feb 2002

Yang Guangwei, Franklin Matthew, Li Jing, Lin T-C, Konigsberg William

Abstract excerpt

We have estimated pre-steady-state kinetic parameters for the addition of a single nucleotide residue by a set of RB69 DNA polymerase mutants in which four highly conserved residues in the fingers domain have been replaced by Ala. The relationship between the kinetic constants exhibited by the mutants and the structure of the ternary complex [Franklin, M., Wang, J., and Steitz T. (2001) Cell 105, 657-667] was...

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PMID: 11851399
DOI: 10.1021/bi0119924

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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