Quantitative analysis of p40/p46 and p69/p71 forms of 2',5'-oligoadenylate synthetase mRNA by competitive PCR and its clinical application.

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Quantitative analysis of p40/p46 and p69/p71 forms of 2',5'-oligoadenylate synthetase mRNA by competitive PCR and its clinical application.

Clinical chemistry - 1 Sept 2002

Takahashi Akira, Iwasaki Yoshiaki, Miyaike Jiro, Taniguchi Hideaki, Shimomura Hiroyuki, Hanafusa Tadashi, Yumoto Yasuhiro, Moriya Akio, Koide Norio, Tsuji Takao

Abstract excerpt

BACKGROUND: 2',5'-Oligoadenylate synthetases (2-5AS) are type I interferon (IFN)-induced proteins with antiviral capacity. Three major forms of 2-5AS with distinct enzymatic activities have been described in IFN-treated human cells. We measured distinct forms of 2-5AS mRNA to analyze the relationship with its enzymatic activity and response to IFN therapy in chronic hepatitis C. METHODS: We established a method...

Topics

2',5'-Oligoadenylate Synthetase
Adult
Aged
Aged, 80 and over
Antiviral Agents
Blotting, Northern
Female
Genotype
Hepatitis C, Chronic
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Interferon-beta

Male

Middle Aged

Polymerase Chain Reaction

RNA, Messenger

Regression Analysis

Tumor Cells, Cultured

Source

Open in PubMed

Identifiers

PMID: 12194933

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Quantitative analysis of p40/p46 and p69/p71 forms of 2',5'-oligoadenylate synthetase mRNA by competitive PCR and its clinical application.PMID 12194933Read ↗

A transcriptional signaling pathway in the IFN system mediated by 2'-5'-oligoadenylate activation of RNase L.Semantic proximity Read ↗

Quantification of hepatitis C virus RNA by competitive reverse transcription and polymerase chain reaction using a modified hepatitis C virus RNA transcript.Semantic proximity Read ↗

Transcriptional induction of the p69 isoform of 2',5'-oligoadenylate synthetase by interferon-beta and interferon-gamma involves three regulatory elements and interferon-stimulated gene factor 3.Semantic proximity Read ↗

[Mechanisms of the effect of interferon (IFN) therapy in patients with type B and C chronic hepatitis].Semantic proximity Read ↗

[2-5 AS activity in serum and peripheral blood mononuclear cells for chronic active hepatitis C and the relationship to clinical outcome of interferon therapy].Semantic proximity Read ↗

Significance of 2',5'-oligoadenylate synthetase activity and HCV genotype in IFN therapy for type C chronic hepatitis.Semantic proximity Read ↗

Upregulation of the 2-5A Synthetase/RNase L Antiviral Pathway Associated with Chronic Fatigue SyndromeSemantic proximity Read ↗

The nature of the catalytic domain of 2'-5'-oligoadenylate synthetases.Semantic proximity Read ↗

Different mechanisms of hepatitis C virus RNA polymerase activation by cyclophilin A and B in vitro.Semantic proximity Read ↗

Effect of interferon treatment on serum 2',5'-oligoadenylate synthetase levels in hepatitis C-infected patients.Semantic proximity Read ↗

Biochemical Evidence for a Novel Low Molecular Weight 2-5A-Dependent RNase L in Chronic Fatigue SyndromeSemantic proximity Read ↗

Acetylsalicylic acid inhibits hepatitis C virus RNA and protein expression through cyclooxygenase 2 signaling pathways.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.