Article
Alpha 8 integrin expression is required for maintenance of the smooth muscle cell differentiated phenotype.
Cardiovascular research - 1 Jul 2006
Zargham Ramin, Thibault Gaétan
Abstract excerpt
OBJECTIVE: Vascular smooth muscle cell (VSMC) de-differentiation is a prerequisite for migration from the tunica media to the intima after vascular injury. Integrin cell adhesion molecules participate in VSMC phenotype modulation. Alpha 8 beta 1 integrin is a differentiation marker of VSMCs and its knockdown heightens migration. In the present study, we examined whether or not alpha 8 integrin is required for the...
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