Article
Plasmodium falciparum mdr1 mutations and in vivo chloroquine resistance in Indonesia.
The American journal of tropical medicine and hygiene - 1 Aug 1999
Gómez-Saladín E, Fryauff D J, Taylor W R, Laksana B S, Susanti A I, Purnomo, Subianto B, Richie T L
Abstract excerpt
Mutations in the Pfmdr1 gene are reported to be associated with chloroquine resistance in some Plasmodium falciparum isolates. A polymerase chain reaction/restriction fragment length polymorphism method was used for the detection of Pfmdr1 mutations in chloroquine-resistant field isolates of P. f...
Topics
- ATP-Binding Cassette Transporters
- Animals
- Antimalarials
- Chloroquine
- Chromatography, High Pressure Liquid
- Drug Resistance
- Electrophoresis
- Genotype
- Humans
- Indonesia
- Malaria
- Mutation
- Plasmodium falciparum
- Polymerase Chain Reaction
- Polymorphism, Restriction Fragment Length
- Protozoan Proteins