Article
The N terminus domain of type VI adenylyl cyclase mediates its inhibition by protein kinase C.
Molecular pharmacology - 1 Sept 1999
Lai H L, Lin T H, Kao Y Y, Lin W J, Hwang M J, Chern Y
Abstract excerpt
Previous results from our laboratory have shown that phosphorylation of type VI adenylyl cyclase (ACVI) by protein kinase C (PKC) caused suppression of adenylyl cyclase activity. In the present study, we investigated the role of the N terminus cytosolic domain of ACVI in this PKC-mediated inhibition of ACVI. Removal of amino acids 1 to 86 of ACVI or mutation of Ser(10) (a potential PKC phosphorylation site) into...
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