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Article

Licensed recombinant hepatitis B vaccines protect chimpanzees against infection with the prototype surface gene mutant of hepatitis B virus.

Hepatology (Baltimore, Md.) - 1 Sept 1999

Ogata N, Cote P J, Zanetti A R, Miller R H, Shapiro M, Gerin J, Purcell R H

Abstract excerpt

The emergence in vaccinated individuals of hepatitis B virus (HBV) mutants with amino acid substitutions within the a determinant of the surface protein has raised the possibility that such variants represent neutralization escape mutants. We previously demonstrated that one such mutant HBV, strain AS, with an arginine substituted for glycine at surface gene codon 145, was infectious and pathogenic in...

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Identifiers

PMID: 10462386
DOI: 10.1002/hep.510300309

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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