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Article

Infectivity and vaccination efficacy studies in animal models of HBV S and pol gene mutants.

Antiviral therapy - 1 Jan 2010

Kamili Saleem

Abstract excerpt

Infectious HBV wild-type and mutant clones were produced in vitro with three mutations in pol (rtV173L plus rtL180M plus rtM204V) or with a single mutation in the S gene (sG145R) and inoculated in treatment-naive chimpanzees. Intravenous inoculation of these mutants in chimpanzees resulted in HBV infection; the pol mutations remained stable, whereas the sG145R mutation reverted to wild type during viraemia....

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Identifiers

PMID: 20516568
DOI: 10.3851/IMP1520

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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