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Article

Vaccine-induced escape mutant of hepatitis B virus.

Lancet (London, England) - 11 Aug 1990

Carman W F, Zanetti A R, Karayiannis P, Waters J, Manzillo G, Tanzi E, Zuckerman A J, Thomas H C

Abstract excerpt

In southern Italy, 44 contacts of hepatitis B virus carriers, including infants of carrier mothers, became HBsAg positive despite passive and active immunisation according to standard protocols. In 32 of these vaccinees infection was confirmed by the presence of additional markers of viral replication. In 1 infant, serious disease occurred. The virus from this patient is an escape mutant with a different sequence...

Topics

Biomarkers
Carrier State
Child, Preschool
Epitopes
Female
Hepatitis B
Hepatitis B Surface Antigens
Hepatitis B virus
Humans
Infant
Infant, Newborn
Italy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Mutation

Vaccination

Viral Hepatitis Vaccines

Virus Replication

Source

Identifiers

PMID: 1697396
DOI: 10.1016/0140-6736(90)91874-a

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1697396-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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