Article
Interaction of Staufen1 with the 5' end of mRNA facilitates translation of these RNAs.
Nucleic acids research - 1 Jan 2005
Dugré-Brisson Samuel, Elvira George, Boulay Karine, Chatel-Chaix Laurent, Mouland Andrew J, DesGroseillers Luc
Abstract excerpt
Staufen1 is a component of transported ribonucleoprotein complexes. Genetic work in Drosophila has suggested that Staufen plays a role in the de-repression of translation of oskar mRNA following localization. To determine whether Staufen1 can play a similar role in mammals, we studied translation of transcripts in the presence or in the absence of Staufen1. Translationally repressed mRNAs were generated by fusing...
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