Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Expression of a dominant-negative Rho-kinase promotes neurite outgrowth in a microenvironment mimicking injured central nervous system.

Acta pharmacologica Sinica - 1 May 2010

Yang Ping, Wen Hui-zhong, Zhang Jin-hai

Abstract excerpt

AIM: To investigate whether lentiviral vector (LV)-mediated expression of a dominant negative mutant Rho-kinase (DNROCK) could inhibit activation of the Rho/ROCK signaling pathway and promote neurite outgrowth in a hostile microenvironment mimicking the injured central nervous system (CNS) in vitro. METHODS: Lentiviral stock was produced using the three-plasmid system by transfecting HEK293 cells. Myelin prepared...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Central Nervous System
Share to Ganglia, Spinal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lentivirus

Share to Myelin Sheath

Share to Nerve Regeneration

Share to Neurites

Share to rho-Associated Kinases

Share to Transduction, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 20383168
DOI: 10.1038/aps.2010.35
PMCID: PMC4002750

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Expression of a dominant-negative Rho-kinase promotes neurite outgrowth in a microenvironment mimicking injured central nervous system.PMID 20383168Read ↗

Pharmacological Modulation of Neurite Outgrowth in Human Neural Progenitor Cells by Inhibiting Non-Muscle Myosin IISemantic proximity Read ↗

p75NTR-dependent, myelin-mediated axonal degeneration regulates neural connectivity in the adult brain.Semantic proximity Read ↗

Adeno-Associated Viral Vectors Serotype 8 for Cell-Specific Delivery of Therapeutic Genes in the Central Nervous SystemSemantic proximity Read ↗

Transgenic activation of Ras in neurons promotes hypertrophy and protects from lesion-induced degeneration.Semantic proximity Read ↗

An update to: Tracking TAU in neurons: How to transfect and track exogenous TAU in primary neuronsSemantic proximity Read ↗

What Is the Role of the Rho-ROCK Pathway in Neurologic Disorders?Semantic proximity Read ↗

NGF-induced moesin phosphorylation is mediated by the PI3K, Rac1 and Akt and required for neurite formation in PC12 cells.Semantic proximity Read ↗

Different roles for RhoA during neurite initiation, elongation, and regeneration in PC12 cells.Semantic proximity Read ↗

High-efficiency transfection of cultured primary motor neurons to study protein localization, trafficking, and functionSemantic proximity Read ↗

Enhancing Structural Plasticity of PC12 Neurons During Differentiation and Neurite Regeneration with a Catalytically Inactive Mutant Version of the zRICH ProteinSemantic proximity Read ↗

The p75 receptor transduces the signal from myelin-associated glycoprotein to Rho.Semantic proximity Read ↗

A neuroprotective agent that inactivates prodegenerative TrkA and preserves mitochondria.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.