Article
Pax6 is implicated in murine pituitary endocrine function.
Endocrine - 1 Apr 1999
Bentley C A, Zidehsarai M P, Grindley J C, Parlow A F, Barth-Hall S, Roberts V J
Abstract excerpt
Pax6, an evolutionarily conserved transcription factor, is expressed in the murine and zebrafish embryonic pituitary, but its role in pituitary development and endocrine function has not been described. To study the role of Pax6 in vivo, we examined Pax6 mutant mouse (SeyNeu) pituitaries. Mice homozygous for the SeyNeu mutation die at birth; therefore, we examined peptide hormone expression by the differentiated...
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