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Two major forms of DNA (cytosine-5) methyltransferase in human somatic tissues

17 Aug 1999

Abstract excerpt

Thus far, only one major form of vertebrate DNA (cytosine-5) methyltransferase (CpG MTase, EC 2.1.1.37) has been identified, cloned, and extensively studied. This enzyme, dnmt1, has been hypothesized to be responsible for most of the maintenance as well as the de novo methylation activities occurring in the somatic cells of vertebrates. We now report the discovery of another abundant species of CpG MTase in...

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PMID: 10449766
DOI: 10.1073/pnas.96.17.9751

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