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Detection of a new 3-base pair insertion mutation in the protease gene of human immunodeficiency virus type 1 during highly active antiretroviral therapy (HAART).

AIDS research and human retroviruses - 1 May 2005

Tramuto Fabio, Bonura Filippa, Mancuso Salvatrice, Romano Nino, Vitale Francesco

Abstract excerpt

To investigate a new insertion mutation in the protease (PR) gene of human immunodeficiency virus type 1 (HIV-1) in a patient extensively pretreated with antiretroviral drugs, genotypic analyses of plasma-derived viruses were performed by sequencing segments of 1302 nucleotides in the pol gene of HIV-1. Despite optimal compliance to highly active antiretroviral therapy (HAART) the patient showed poor virological...

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PMID: 15929706
DOI: 10.1089/aid.2005.21.420

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