Ten years of genes in inherited arrhythmia syndromes: an example of what we have learned from patients, electrocardiograms, and computers.

Abstract excerpt

In the last 10 years the molecular substrate of a diversity of primary electrical diseases has been unraveled. Disease-causing mutations in ion-channel genes have been identified and have challenged clinical and basic electrophysiologists to mechanistically link the observed genetic aberrancies to the phenotype. Indeed, in collaborative efforts of clinical cardiologists, clinical and molecular geneticists, basic...

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