Article
Variants of endothelin-1 and its receptors in atopic asthma.
Biochemical and biophysical research communications - 19 Aug 1999
Mao X Q, Gao P S, Roberts M H, Enomoto T, Kawai M, Sasaki S, Shaldon S R, Coull P, Dake Y, Adra C N, Hagihara A, Shirakawa T, Hopkin J M
Abstract excerpt
Endothelin-1 (ET-1) is a 21 amino acid peptide released from several types of bronchial cells. It operates through two types of receptors, type A(ET-RA) and type B(ET-RB) and has various activities in the pathophysiology of atopic asthma. These genes are localised on different chromosomes where genome-wide searches have identified linkage for atopic asthma, thus supporting the candidacy of ET-1 and its receptors...
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