Article
ETB receptor polymorphism is associated with airway obstruction.
BMC pulmonary medicine - 30 Apr 2007
Taillé Camille, Guénégou Armelle, Almolki Abdelhamid, Piperaud Marie, Leynaert Bénédicte, Vuillaumier Sandrine, Neukirch Françoise, Boczkowski Jorge, Aubier Michel, Benessiano Joëlle, Crestani Bruno
Abstract excerpt
BACKGROUND: Endothelin-1 (EDN1) has been involved in the development of airway obstruction and inflammation in asthma. Several polymorphisms have been identified among the genes encoding for preproET1, an inactive precursor of ET-1, and for ETA (EDNRA) and ETB (EDNRB), the two receptors for EDN1. In the present work, we hypothesised that molecular variation in these genes could be a major determinant of the...
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