Article
A common variant in RAB27A gene is associated with fractional exhaled nitric oxide levels in adults.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology - 1 Apr 2015
Bouzigon E, Nadif R, Thompson E E, Concas M P, Kuldanek S, Du G, Brossard M, Lavielle N, Sarnowski C, Vaysse A, Dessen P, van der Valk R J P, Duijts L, Henderson A J, Jaddoe V W V, de Jongste J C, Casula S, Biino G, Dizier M-H, Pin I, Matran R, Lathrop M, Pirastu M, Demenais F, Ober C
Abstract excerpt
BACKGROUND: Exhaled nitric oxide (FeNO) is a biomarker for eosinophilic inflammation in the airways and for responsiveness to corticosteroids in asthmatics. OBJECTIVE: We sought to identify in adults the genetic determinants of fractional exhaled nitric oxide (FeNO) levels and to assess whether environmental and disease-related factors influence these associations. METHODS: We performed a genome-wide association...
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