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Article

Unbalanced germ-line expression of hMLH1 and hMSH2 alleles in hereditary nonpolyposis colorectal cancer.

Cancer research - 1 Aug 1999

Curia M C, Palmirotta R, Aceto G, Messerini L, Verì M C, Crognale S, Valanzano R, Ficari F, Fracasso P, Stigliano V, Tonelli F, Casale V, Guadagni F, Battista P, Mariani-Costantini R, Cama A

Abstract excerpt

We analyzed the hMLH1 and hMSH2 genes in 30 unrelated hereditary nonpolyposis colorectal cancer (HNPCC) patients using mutational and immunohistochemical analyses combined whenever possible with primer extension assays, designed to estimate hMLH1 and hMSH2 transcript expression in peripheral blood lymphocytes. Single-strand conformational polymorphism screening and PCR-direct sequencing revealed seven hMLH1 and...

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Share to Adaptor Proteins, Signal Transducing
Share to Colorectal Neoplasms, Hereditary Nonpolyposis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Heterogeneity

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Share to MutL Protein Homolog 1

Share to MutS Homolog 2 Protein

Share to Polymorphism, Single-Stranded Conformational

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Identifiers

PMID: 10446963

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Unbalanced germ-line expression of hMLH1 and hMSH2 alleles in hereditary nonpolyposis colorectal cancer.PMID 10446963Read ↗

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Systematic analysis of hMSH2 and hMLH1 in young colon cancer patients and controls.Semantic proximity Read ↗

Loss or somatic mutations of hMSH2 occur in hereditary nonpolyposis colorectal cancers with hMSH2 germline mutations.Semantic proximity Read ↗

Involvement of hMSH6 in the development of hereditary and sporadic colorectal cancer revealed by immunostaining is based on germline mutations, but rarely on somatic inactivation.Semantic proximity Read ↗

Mutations of hMLH1 and hMSH2 in patients with suspected hereditary nonpolyposis colorectal cancer: correlation with microsatellite instability and abnormalities of mismatch repair protein expression.Semantic proximity Read ↗

Immunohistochemistry for hMLH1 and hMSH2: a practical test for DNA mismatch repair-deficient tumors.Semantic proximity Read ↗

Reduced mRNA expression in paraffin-embedded tissue identifies MLH1- and MSH2-deficient colorectal tumours and potential mutation carriers.Semantic proximity Read ↗

Pathogenicity of missense and splice site mutations in hMSH2 and hMLH1 mismatch repair genes: implications for genetic testing.Semantic proximity Read ↗

Seven new mutations in hMSH2, an HNPCC gene, identified by denaturing gradient-gel electrophoresis.Semantic proximity Read ↗

A truncated hMSH2 transcript occurs as a common variant in the population: implications for genetic diagnosis.Semantic proximity Read ↗

hMLH1 and hMSH2 expression correlates with allelic imbalance on chromosome 3p in non-small cell lung carcinomas.Semantic proximity Read ↗

RNA-based mutation screening in hereditary nonpolyposis colorectal cancer.Semantic proximity Read ↗

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