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Article

RNA-based mutation screening in hereditary nonpolyposis colorectal cancer.

American journal of human genetics - 1 Oct 1996

Kohonen-Corish M, Ross V L, Doe W F, Kool D A, Edkins E, Faragher I, Wijnen J, Khan P M, Macrae F, St John D J

Abstract excerpt

Hereditary nonpolyposis colorectal cancer (HNPCC) is a cancer syndrome inherited in an autosomal dominant fashion. Four susceptibility genes are known, which code for DNA mismatch repair enzymes. The purpose of this study was to identify the HNPCC gene defects in a cohort of Australian HNPCC families and to evaluate the use of RNA-based screening methods. Six mutations were identified, four in the hMLH1 gene and...

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PMID: 8808596
PMCID: PMC1914793

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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