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Article

Systematic analysis of hMSH2 and hMLH1 in young colon cancer patients and controls.

American journal of human genetics - 1 Sept 1998

Farrington S M, Lin-Goerke J, Ling J, Wang Y, Burczak J D, Robbins D J, Dunlop M G

Abstract excerpt

Germ-line mutations in DNA mismatch-repair genes impart a markedly elevated cancer risk, often presenting as autosomal dominant hereditary nonpolyposis colorectal cancer (HNPCC). However, there are no pathognomonic features of HNPCC, not all gene carriers have a family history of the disease, and families fulfilling the Amsterdam criteria are relatively uncommon. Genetic testing of probands with early-onset...

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Identifiers

PMID: 9718327
DOI: 10.1086/301996
PMCID: PMC1377385

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Systematic analysis of hMSH2 and hMLH1 in young colon cancer patients and controls.PMID 9718327Read ↗

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Seven new mutations in hMSH2, an HNPCC gene, identified by denaturing gradient-gel electrophoresis.Semantic proximity Read ↗

Mismatch Repair and the Hereditary Non-polyposis Colorectal Cancer Syndrome (HNPCC)Semantic proximity Read ↗

Sixteen rare sequence variants of the hMLH1 and hMSH2 genes found in a cohort of 254 suspected HNPCC (hereditary non-polyposis colorectal cancer) patients: mutations or polymorphisms?Semantic proximity Read ↗

Prevalence of alterations in DNA mismatch repair genes in patients with young-onset colorectal cancer.Semantic proximity Read ↗

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