Systematic analysis of hMSH2 and hMLH1 in young colon cancer patients and controls.

doi:10.1086/301996

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Article

Systematic analysis of hMSH2 and hMLH1 in young colon cancer patients and controls.

American journal of human genetics - 1 Sept 1998

Farrington S M, Lin-Goerke J, Ling J, Wang Y, Burczak J D, Robbins D J, Dunlop M G

Abstract excerpt

Germ-line mutations in DNA mismatch-repair genes impart a markedly elevated cancer risk, often presenting as autosomal dominant hereditary nonpolyposis colorectal cancer (HNPCC). However, there are no pathognomonic features of HNPCC, not all gene carriers have a family history of the disease, and...

Topics

Adaptor Proteins, Signal Transducing
Adult
Age Factors
Carrier Proteins
Colonic Neoplasms
Colorectal Neoplasms
Colorectal Neoplasms, Hereditary Nonpolyposis
DNA Repair
DNA-Binding Proteins
Exons
Female

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Male

Microsatellite Repeats

MutL Protein Homolog 1

MutS Homolog 2 Protein

Mutation

Neoplasm Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 9718327
DOI: 10.1086/301996
PMCID: PMC1377385

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9718327-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Systematic analysis of hMSH2 and hMLH1 in young colon cancer patients and controls.PMID 9718327Read ↗

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