Article
Altered expression of hMSH2 and hMLH1 in tumors with microsatellite instability and genetic alterations in mismatch repair genes.
Cancer research - 1 Nov 1996
Thibodeau S N, French A J, Roche P C, Cunningham J M, Tester D J, Lindor N M, Moslein G, Baker S M, Liskay R M, Burgart L J, Honchel R, Halling K C
Abstract excerpt
To date, at least four genes involved in DNA mismatch repair (MMR) have been demonstrated to be altered in the germline of patients with hereditary nonpolyposis colon cancer: hMSH2, hMLH1, hPMS1, and hPMS2. Additionally, loss of MMR function has been demonstrated to lead to the phenomenon of microsatellite instability (MIN) in tumors from these patients. In this study, we have examined the protein expression...
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