Mutations of hMLH1 and hMSH2 in patients with suspected hereditary nonpolyposis colorectal cancer: correlation with microsatellite instability and abnormalities of mismatch repair protein expression.

doi:10.1200/JCO.2002.20.5.1203

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Article

Mutations of hMLH1 and hMSH2 in patients with suspected hereditary nonpolyposis colorectal cancer: correlation with microsatellite instability and abnormalities of mismatch repair protein expression.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 1 Mar 2002

Scartozzi Mario, Bianchi Francesca, Rosati Saverio, Galizia Eva, Antolini Annalisa, Loretelli Cristian, Piga Andrea, Bearzi Italo, Cellerino Riccardo, Porfiri Emilio

Abstract excerpt

PURPOSE: The relationship between germ-line mutations of hMSH2 and hMLH1, microsatellite instability (MSI), and loss of DNA mismatch repair (MMR) gene expression were studied to formulate an effective selection protocol for patients with suspected hereditary nonpolyposis colorectal cancer who should be offered genetic testing. PATIENTS AND METHODS: Patients eligible for germ-line analysis of hMLH1 and hMSH2 were...

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PMID: 11870161
DOI: 10.1200/JCO.2002.20.5.1203

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